Lecture 1

• Mouse Lecture 1 (pdf)
• Beck et al. (2000) Genealogies of mouse inbred strains. Nature Genetics 24
• Bolivar et al. (2002) Mapping of Quantitative Trait Loci with Knockout/Congenic Strains Genes & Dev 11:1549-1552.
• Fraser et al. (2007) A sequence-based variation map of 8.27 million SNPs in inbred mouse strains Nature 448:1050-
• Peirce (2001) Looking at Old Tools in New Ways: Using Knockouts as Congenics to Study QTLs Genes & Dev 11:1469-1471
• Snell (1980) Studies in Histocompatibility
• Wakeland et al. (1997) Speed congenics: a classic technique in the fast lane (relatively speaking) Immunology Today
• Yang et al. (2007) On the subspecific origin of the laboratory mouse Nature Genetics 39:1100

Lecture 2

• Mouse Lecture 2 (pdf)
• The Complex Trait Consortium. The Collaborative Cross, a community resource for the genetic analysis of complex traits (2004) Nature Genetics 36:1133
• Gregorová et al. (2008) Mouse consomic strains: Exploiting genetic divergence between subspecies Mus m. domesticus and Mus m. musculus Genome Research 18:509–515.
• Nadeau et al. (2000) Analysing complex genetic traits with chromosome substitution strains Nature Genetics 24:221-225
• The GeneNetwork Sample 1, Sample 2

Lecture 3

• Mouse Lecture 3 (pdf)
• Chen et al. (2007) Genetic and Genomic Insights into the Molecular Basis of Atherosclerosis Cell Metabolism 6:164-176
• Sheehan et al. (2008) Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice. Am J Physiol Renal Physiol 293: F1649–F1656.
• Stylianou et al. (2008) Applying Gene Expression, Proteomics and Single-Nucleotide Polymorphism Analysis for Complex Trait Gene Identification. Genetics 178:1795-1805.
• Wagner et al (2008) Pleiotropic scaling of gene effects and the ‘cost of complexity’ Nature 45:470- 472.
  

Lecture 4

• Mouse Lecture 4 (pdf)
• Brystrykh et al. (2005) Uncovering regulatory pathways that affect hematopoietic
  stem cell function using ‘genetical genomics’ Nature Genetics 37:225-232
• Chesler et al (2005) Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nature Genetics 37:233-242
• Ferrara et al. (2008) Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling PLoS Genetics 4:
• Sladek & Hudson (2006) Elucidating cis- and trans-regulatory variation using genetical genomics. TRENDS in Genetics 22:245-
• Kukla et al (2009) Coding-Sequence Determinants of Gene Expression in Escherichia coli Science 324:255-
• Williams et al (2006) Normalization procedures and detection of linkage signal in genetical-genomics experiments. Nature 38:855
  

Other Resources

• Textbook-“Mouse Genetics - Concepts and Applications” (1995) Lee Silver, Oxford University Press www.informatics.jax.org/silver/
• Mouse Genome Bioinformatics Links

Previous Exams

• 2008

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