Waksman Institute

Rutgers, the State University of New Jersey

Research

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Yeast Labs on Campus

Transcription Labs on Campus

Microbiology and Molecular
Genetics Graduate Program

Department of Molecular Biology
and Biochemistry

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The main focus of our research is on the regulation of transcription in the yeast Saccharomyces cerevisiae. Specifically, we are investigating how different regulatory proteins interact to control gene expression and how these interactions influence the regulatory function of the proteins. We have chosen three systems to study this problem:

1) Examining the mechanism of repression by the yeast Mata2 protein, a cell-type specific repressor involved in mating-type regulation;

2) Examining the molecular interactions of the Mcm1 protein, a MADS-Box protein that is involved in the transcriptional regulation of cell type, cell-cycle and metabolic pathways, and

3) Investigating factors involved in the regulation of transcription at the middle stages of meiosis.

There are also several other projects in the lab that:

4) Investigate the role of the Sfp1 protein in regulation of ribosome biosynthesis genes;

5) Examine how depletion of the histone H2A-H2Bdimer causes arrest during meiosis;

6) Investigate the role of induction of specific mitochondrial ribosomal genes during meiosis;

7) Investigate the role of the PRY genes, homologs of plant pathogen defense genes, in yeast